38 Nurturing a customer relationship from compound development to patent filing Background In late 2019, Sai Life Sciences partnered with a neuroscience biotech company with focus on harnessing the power of psychoplastogens - novel neuroplasticity-promoting therapeutics - for treating mental health disorders at scale. Action Taken A consistent flow of deliverables from three full-time FTEs at Sai enabled the customer to file six significant patent applications under tight timelines. More than 1,800 compounds were developed for the customer till date and more compounds are in the clinical phase. Making it better in Manchester with the first batch of GMP API Action Taken: The team has identified the scope for process development aiming at a safe and robust process that can consistently deliver requisite purity and yield. Usage of bromine in the process was eliminated, without impacting the product yield and quality. • Usage of benzoyl peroxide along with 25% moisture which keeps the reagent stable. Eliminated the risk of benzoyl peroxide decomposition which leads to potential explosion • Deployed slow temperature ramping protocol which has made the process completely safe to execute at different scales • The samples were collected intermittently and analysed at a range of temperatures (at 30°C, 40°C, 50°C, 60°C, 70°C, and 80°C) to understand the true exothermicity temperature range with respect to reaction conversion • Since initiating a reaction causes an exotherm to start at 72°C, a hooter device was proposed and installed to alert people and trigger a quick action if the mass temperature exceeded the threshold Sustainable Practices in Medicinal Chemistry
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