46 Resource efficiency We are committed to optimizing resource usage across all our operations. Through innovative technologies and best practices, we aim to reduce our consumption of water, energy, and raw materials, thereby minimizing our ecological footprint while enhancing operational efficiency. Materials We recognize the critical importance of sustainable material management in minimizing our environmental impact and catalyzing growth. We commit to a simple philosophy in making right choices to support our commitment to environmental Material Optimization • Solvent Selection: Prioritizing the use of greener solvents and implementing solvent minimization techniques. • Superficial Fluid Chromatography (SFC): We have doubled our SFC capacity to reduce the usage of multiple solvents like hexane and heptane, commonly used in conventional purification processes. SFC, a green chromatographic technique, utilizes more environmentally friendly solvents, including liquid CO2, leading to a 70% • reduction in organic solvent consumption. This approach also minimizes waste solvent generation by adopting greener processes. • Combi Flash Technique: For small-scale lab purification, we use the Combi flash technique instead of conventional column purification methods. This technique consumes less solvent as the mobile phase while providing efficient purification of crude compounds, further contributing to solvent reduction and environmental sustainability. Material Efficiency • Optimizing material usage across our operations to reduce waste and conserve resources. • Parallel Synthesis in R&D: We have introduced a parallel synthesis approach at our R&D unit, allowing multiple reactions to be set up on a milligram scale. This method eliminates the need for large-scale setups to observe product formation, thereby reducing material usage and enhancing efficiency in the process. • Process Optimization in Manufacturing: In our manufacturing unit, we have eliminated in-process sampling for one of our product by optimizing processes and utilizing trend analysis from previous data as a standard reference. This has significantly reduced the number of samples tested and the hazardous waste generated from sample analysis activities. • Electronic Lab Notebook Book Implementation: As part of our sustainability initiatives, nearly 450 chemists in our labs have transitioned from paper-based lab notebooks to electronic lab books. This shift has greatly reduced paper waste and conserves the resources typically used in paper production, supporting our commitment to environmental conservation. Life Cycle Assessment (LCA) We are developing an action plan to undertake assessments to evaluate the environmental impact of materials and identify opportunities for improvement. Material Reuse and Recycling Solvent Recovery and Reuse: Implementing solvent recovery systems to reduce waste and lower costs. At our manufacturing unit, we utilize a Solvent Recovery System (SRS) to recover solvents specifically for dedicated products. During the process, the mother liquor generated, which contains both organic and aqueous layers, is carefully treated. The organic layer, rich in solvents, is processed through a fractionation column at controlled temperatures to recover the solvents effectively. The reclaimed solvent is then reused in the production process, minimizing waste and enhancing resource efficiency. Electronic Lab Book Implementation: The number of pages eliminated due to migration from paper based e- lab notebooks to Biovia ELN is ~2.25 Lakh papers that is equivalent to offsetting 198 tCO2. Solvent Quantity (KL) Ipa (isopropyl alcohol) 86 Methyl isobutyl ketone 12 Mono chlorobenzene 12 N-butanol 149 Ethyl Acetate 41 Total 300 Solvent recycled and reused: FY 23-24 Solvent recycled and reused FY:22-23 Solvent Quantity (KL) Isopropyl alcohol 58 N-Butanol 85 Toluene 111 Treated Ethyl Acetate 21 Ethyl Acetate 41 Total 316 Waste Minimization: Employing waste reduction strategies and optimizing recycling programs for various materials. • In Medicinal Chemistry labs, oil baths are replaced with Aluminium beads for heating reactions. This has eliminated waste oil generation from the process. • Use of glass droppers in labs to avoid the generation of plastic syringes. Nearly 10% of plastic syringes waste have been reduced. Closed-Loop Systems: Exploring opportunities to create closed-loop systems for material reuse within our operations. • In CRIMS, 30% of chemicals have been reused by developing in-house inventory and software based tracking system.
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