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Delivering selective and sustainable Chemocatalytic processes

Chemocatalysis is employed in routes of synthesis to effect superior selectivity, yield and atom economy. The optimisation of a chemocatalytic reaction requires multiple experiments to identify optimal conditions such as catalyst, it’s loading, the solvent, temperature and pressure. Sai Life Sciences has the capability for high throughput screening combined with Design of Experiments (DoE) to study a range of chemocatalytic processes that can ensure a smooth scale-up from gram to multi kilo scale.

Chemocatalysis

Highlights

  • Proven track record of leveraging chemocatalysis
  • Experience spanning from gram to multi kilo scale
  • Consistently meet or exceed customer expectations on catalyst loading, reaction time and product isolation
  • Strong team across Manchester and Hyderabad with extensive experience in the field
  • Robust network with all leading catalyst developers and manufacturers ensuring quick availability at lab, pilot and manufacturing scale
  • Offer FTE collaboration for new route scouting projects

Capabilities

  • Routine evaluation of projects for opportunities to implement chemocatalysis
  • Parallel screening equipment for homogeneous and heterogeneous catalysts with dedicated analytical support
  • Hydrogenation and reaction screening and optimisation at high pressure and temperature
  • KitAlaysisTM high throughput screening kits for a variety of reactions
  • Efficient removal of metals to the desired specification using various metal scavengers and filtration techniques
  • Accurate metal analysis with in-house ICP-MS
  • Continuous upgrade and modernisation of chemocatalysis capabilities
Chemocatalysis

Infrastructure

  • Radleys Carousels (12 reactions from 1ml to 20ml;
    Temp: – 78oC to 220oC
  • Software-enabled Radleys Mya-4 (4 to 32 reactions
    from 2 to 250ml; Temp: -20oC to 180oC)
  • Fully automated AmigoChem Integrity 10
    (Temp: -30oC to 150oC)
  • HEL PolyBlock 4 (4 independent reaction zones;
    Temp: -60oC to 225oC)
  • Hydrogenation and pressure reactions
    • HEL Chemscan (40-50ml; Temp: -20oC to 225oC;
    Pressure: up to 12 bar)
    • Amar Instruments (100ml; Temp: 0oC to 300oC;
    Pressure: up to 80 bar)
  • Andrews Alliance Robot to accelerate liquid handling

Illustrative Cases

  • Asymmetric hydrogenation of acetophenone derivative at 2kg scale with 4 mol% catalyst (Yield: 85%; ee: >99.5%)
  • Asymmetric hydrogenation of cyclic ketones demonstrated at 100kg scale with 2 mol% catalyst (Yield: 85-90%; ee: >99%)
  • Asymmetric transfer hydrogenation to produce 1,3-diamines (Yield: 75%; ee>95%)
  • Refined Suzuki cross-coupling to demonstrate a 73% isolated yield on >150g scale, ready for further scale-up