Process R&D laboratory
at Alderley Park, Manchester, UK

Instruments and Capabilities

• Buchi Versoclave and Large Scale Kiloclave Pressure Vessel Systems: Extremely versatile systems with interchangeable vessels from 1L to 20L. Enables process development and production with enhanced data logging for subsequent technical transfer to manufacturing plant.
• Radleys Mya 4 Reaction Station: A 4-zone reaction station o­ffering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
• Radleys Reactor-Ready™ Lab Reactor: Reactor-Ready is designed as a universal reactor workstation with a range of easily interchangeable vessels from 100 ml to 5 litres which can be configured to suit the chemistry and scale needed for each project. Ava software control is installed, allowing control loops, programmable operations and data logging.
• Radleys Carousel 12 Plus Reaction Station™: The patented Carousel 12 Plus simultaneously heats/cools, stirs and refluxes multiple samples under an inert atmosphere. An eff­ective personal synthesis station for parallel solution phase chemistry and solid-supported reagent-based synthesis.

• Radleys Reactor-Ready™ Pilot Lab Reactor: Three systems, allowing multiple vessel configurations from 10L to 20L with low temperature (<-60°C) capability and one stream operating to cGMP.
• Amigochem Integrity 10™ Parallel Reaction Block: The Integrity 10™ reactor block supersedes the very successful model RS10 (over 400 units installed world-wide). The new unit incorporates a huge wealth of user experience into an enhanced design. Enhancements include refined temperature control and improved reliability via the removal of the reactor cells from the electronics compartment.
• HEL ChemSCAN II | Catalyst Screening & Parallel Process Development System: Fast, efficient screening of 8 reactions up to 200 bar. The ChemSCAN II is a dedicated parallel reaction system for the rapid development of high-pressure reactions and heterogeneous catalysis systems.
• HEL TSu | Thermal Screening Unit for Explosion Hazards Liquids and Powders: Rapid screening of thermal hazards using 0.5 to 5g sample to generate both temperature and pressure data. Hence this can be considered an improvement over the classical DSC method.
• Teledyne CombiFlash Torrent®: The next generation for scale-up of flash purification. This system off­ers method development and development scale purification of 300g sample per run using flow rates of up to 1 litre per minute.
• Analytical Separations: UPLC and HPLC with UV, diode array and MS detection. GC/FID with headspace and split injection.
• Spectroscopy: FTIR, multinuclear NMR, UV, GC/MS and accurate mass electrospray LC/MS. Access to ICP via external contract analysis.
• Classical Methods: Karl Fischer, automated titrations, loss on drying and sulfated ash.
• Physical Properties Testing: XRPD, Laser Diffraction Particle size, DSC, TGA and access to other physical properties characterisation techniques via external contract analysis.
• Stability Testing: Execution of forced-degradation studies and ICH Q1a/Q1b stability testing suitable for development purposes or CMC regulatory submissions.
• High Throughput Experimentation: Using state of the art automation, Sai Manchester can now offer High Throughput Experimentation (HTE) to accelerate reaction optimisation, discovery of new reactions and other aspects of process design and development.