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Integrated R&D campus for Discovery R&D, CMC process development & clinical phase manufacturing

The Integrated Discovery & Development Campus (Unit II) enables us to provide scientific solutions and supports a comprehensive suite of services, ranging from early-phase discovery, preclinical development, and clinical development, through to commercial manufacturing. This 12-acre campus in Hyderabad serves our customers globally, ensuring a seamless integration of all phases of drug development cycle.

Illustrated site plan of Sai Life Sciences' Integrated Discovery & Development Campus in Hyderabad, highlighting key facilities including the Biology Center of Excellence, Integrated Discovery Services, Research & Technology Block, Med Chem Blocks, Scale-up Labs, and future expansion areas

Discovery facilities

Sai Life Sciences' Integrated Campus in Hyderabad, featuring modern architecture, lush greenery, and sustainable infrastructure for pharmaceutical research and innovation.

Medicinal Chemistry highlights

  • 360+ fume cupboards, all < 3 years old
  • Each lab is self-contained with dedicated LC-MS for reaction monitoring Radleys Parallel Synthesizers, 5 CombiFlash® and other complementing infrastructure
  • Industry-benchmark analytical support

Biology highlights

  • >11000 sq. ft. of lab space; Custom assay development
  • Throughput screening & SAR support, Cell line generation, Cell assays & High content screening, Protein production, Biochemical assays, SPR, Electrophysiology
  • Target engagement/PK-PD studies Biomarker assessments, Efficacy models
Sai Life Sciences' Biology Building at the Hyderabad Integrated Campus, a cutting-edge facility for advanced biological research and drug discovery.
Scientist at Sai Life Sciences' Hyderabad Integrated Campus working with an advanced Biomek i7 automation system for high-throughput DMPK research and drug metabolism studies.

DMPK highlights

  • 18000 sq. ft. of lab space
  • Fully integrated automated Wave-1 ADME, IDOT, API7500, HRMS, large cell culture suites, validated drug transporter assays, IND packages
  • Organoid technology AAALAC accredited Vivarium, OLAW certified labs, state of art histopathology

Developability & Formulations highlights

  • Pre-formulation packages-customised or extensive, including physicochemical profiling, solubility profiling, dissolution, solid-state, crystallinity assessment, hygroscopicity and bulk behaviour.
  • Particle size reduction (micronisation) capability- to be added in next 3-6 months.
  • Amorphous screening (spray drying)- to be added in next 3-6 months.
  • Stability evaluation of compounds and preclinical formulations

 

 

Sai Life Sciences' developability and formulations laboratory at the Hyderabad Integrated Campus, designed for advanced pharmaceutical research and drug formulation development.

CMC facilities

Process R&D and Analytical Development highlights

Sai Life Sciences' Integrated Campus in Hyderabad, a state-of-the-art research and manufacturing facility set in a modern, green environment.

Process R&D highlights

  • 120 fume cupboards, parallel experimentation, jacketed lab reactors, fully equipped Analytical R&D Labs, Process Engineering & Pilot Scale Facility, 1µg/m3 containment
  • Technologies – Bio Catalysis, Chemo Catalysis, Flow chemistry, Particle Formation, Nucleosides & Phosphoramidites
  • HPAPI Labs, Process Safety lab
  • Dedicated team for early phase chemistry – pre-clinical
    to First-in-Human GMP supplies

 

Analytical Development highlights

  • Method development & validation
  • Solid state characterization
  • Structure confirmation
  • GTI determination
  • Other specialized techniques
  • Isolation & purification
Scientists at Sai Life Sciences' Hyderabad Integrated Campus conducting analytical development using advanced chromatography systems for pharmaceutical research and quality control.
Scientists working in Sai Life Sciences' dedicated GMP plant at the Hyderabad Integrated Campus, featuring advanced pharmaceutical manufacturing and quality control systems

Early phase scale up highlights

  • 10 reactors of sizes ranging from 100L to 350L
    • MoC
      • Stainless steel
      • Glass-lined
      • Hastelloy
  • 80L and 140L Hastelloy ANFD
  • -100 to +180C range
  • 1ug/m3 containment
  • PLC controls and automation

Process technology highlights

  • Bio Catalysis
  • Chemo Catalysis
  • Flow Chemistry
  • Particle Engineering
  • ATFE & Short Path distillation
  • Liquid-Liquid Extraction
  • Lyophilisation
  • HPAPI
  • Nucleosides & Phosphoramidites
Scientist at Sai Life Sciences' Hyderabad Integrated Campus handling a Lyomax freeze-dryer for lyophilization scale-up in pharmaceutical development.
Advanced liquid-liquid extraction system at Sai Life Sciences' Hyderabad Integrated Campus, featuring FlowTech pumps and precision-controlled separation processes for pharmaceutical research
State-of-the-art particle engineering setup at Sai Life Sciences' Hyderabad Integrated Campus, featuring precision analytical instruments for advanced pharmaceutical formulation development.
Advanced flow chemistry setup at Sai Life Sciences' Hyderabad Integrated Campus, featuring precision-controlled reactors and methanol-based chemical processing.
Scientist at Sai Life Sciences' Hyderabad Integrated Campus operating advanced laboratory equipment for pharmaceutical research and manufacturing.
Scientist at Sai Life Sciences' Integrated Campus in Hyderabad conducting a precision chemical experiment, highlighting advanced research and development capabilities.