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Amidites, Linkers/Spacers, and Lipids Capabilities

Amidites, Linkers/Spacers, and Lipids Capabilities

Amidites

Sai Life Sciences offers end-to-end services across R&D to manufacturing of Amidites. With higher numbers of oligonucleotide therapeutics set to hit the market in the coming days, the R&D and manufacturing of amidites will be a crucial aspect for pharma & biotech companies and we at Sai Life Sciences are ready to meet the unique needs of our customers.

Our Capabilities include:

  • 35-member dedicated team
  • End-to-end capabilities: R&D – Tech Transfer – Pilot Scale – Commercial Production
  • Dedicated Phosphoramidites manufacturing facility

Lipids

Sai Life Sciences has experience in synthesizing a single category of lipids called Saccharolipids/lipopolysaccharides. Lipids are a broad group of organic compounds which include fats, fat-soluble vitamins, mono, di-glycerides, and phospholipids. Functions of lipids include storing energy, signaling, and acting as a structural component of cell membranes.

Our Experience

  • Developed low temperature crystallization for low melting lipid intermediates and implemented on multi-100 kg scale
  • Implemented liquid-liquid extraction to purge the impurities and enhanced purity of lipid intermediates
  • Established analytical method for in-process and intermediates of lipid intermediates using latest CAD technology across the synthesis

Linkers/Spacers

At Sai Life Sciences, we can prepare the protected Spacer and Linker individually and then prepare the 3′-triantennary or 5′-triantennary. Linkers/Spacers is used for Oligonucleotide conjugates. By conjugating it directly to the Oligonucleotides or decorating it to a certain delivery system as a targeting moiety, Linkers/Spacers can succeed in the development of nucleic acid therapeutics. Route of Synthesis.

Areas of expertise in multi-kg scale

  • Aza-Micheal reaction
  • EDCI mediated peptide bond formation with impurity knowledge
  • Tri-antennary intermediate synthesis
  • Tri-amide bond formation
  • Hydrogenolysis of benzyl group
  • Hands on experience in Boc-protection followed by ester reduction on proline intermediate.
  • DMTr protection for various sugar moieties

Areas of expertise in multi-100 g scale

  • Succinate opening with six-membered derivative on analogous intermediate
  • Glycosylation with exclusive β-selectivity
  • Hydrogenolysis of benzyl group
AR&D