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Amidites Capabilities

With a growing number of oligonucleotide therapeutics set to enter the market in the coming days, the timely development and manufacturing of high-quality phosphoramidites will be crucial for pharma and biotech companies. At Sai Life Sciences, we are ready to meet the unique needs of our customers. We offer end-to-end services, from R&D to the manufacturing of phosphoramidites.

Amidites, Linkers/Spacers, and Lipids Capabilities
AR&D

Highlights

  • Chemical modification of ribose sugar moiety & nucleobase
  • DNA end capping spacer amidites
  • 2’-Deoxy Phosphoramidites
  • 2’-O-Methyl Phosphoramidites
  • 2’-Fluoro Phosphoramidites
  • 2’-O-Methoxymethyl Phosphoramidites
  • Bridged Nucleosides & Phosphoramidites
  • Morpholino Phosphorodiamidates
  • Custom synthesis, development, and manufacturing
  • Proprietary nucleoside product exclusive for our partner

Infrastructure

  • Dedicated Phosphoramidite lab with Radleys Mya4 reaction station and double jacketed reactors at the R&T facility
  • Exclusive Phosphoramidite manufacturing facility with
    • Single fluid utilities for better temperature control
    • Raw material / KSM charging by closed method through Powder Transfer System / Drum Containment System
    • Closed unloading from ANFDs / Nauta dryer through continuous liner bags to avoid the external exposure
    • Closed-loop sampling system to take the samples from ANFDs / Nauta for in-process / final test
    • Nauta Dryer/ANFD for exclusive drying of phosphoramidites

Capability

End-to-end capabilities: R&D – Tech Transfer – Pilot Scale – Commercial Production