Lipids and Linkers/Spacers Capabilities
Charting out new pathways of Drug Development. Fast.
Lipids
Sai Life Sciences has experience in synthesizing a single category of lipids called Saccharolipids/lipopolysaccharides. Lipids are a broad group of organic compounds which include fats, fat-soluble vitamins, mono, diglycerides, and phospholipids. Functions of lipids include storing energy, signalling, and acting as a structural component of cell membranes.
Highlights
- Phosphorylated glucosamine disaccharide decorated with multiple fatty acids
- Developed low temperature crystallization for low melting lipid intermediates and implemented on multi-100 kg scale
- Implemented liquid-liquid extraction to purge the impurities and enhanced purity of lipid intermediates
- Established analytical method for in-process and intermediates of lipid intermediates using latest CAD technology across the synthesis
Our Capabilities
- Dedicated process development team
- Purification techniques
- Multi kg production
Our Infrastructure
- Scale up capacity at multi kg scale synthesis
- Downstream equipment
Linkers/Spacers
GalNAc conjugation is now one of the leading strategies for delivering experimental oligonucleotide drugs. GalNAc is a carbohydrate moiety that recognize and bind to cell surface protein. Based on the therapeutic needs, it has been decorated with various spacers, linkers, and backbones for the delivery of oligonucleotides. Sai support in R&D followed by large scale manufacturing of structural variants of GalNAc conjugates.
Highlights
- Expertise in multi-kg scale to support the clients Lab to commercial requirements
- Aza-Micheal reaction – Glycosylation – Coupling with linkers
- Peptide bond formation with various coupling reagents like EDC, T3P, pyBOP with complete impurity profiling
- Tri-antennary intermediate synthesis
- Tri-amide bond formation
- Hydrogenolysis of benzyl group and other protection-deprotection strategies with Green Chemistry concepts
- Hands on experience in multi kilogram scale for Fmoc, Cbz, Benzyl, Benzoyl, Boc-protection and deprotections in multikilogram scales
- DMTr protection for various sugar moieties
Our Capabilities
- mg to Multi kilograms
Our Infrastructure
- All development – pilot and scale up support
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