Oligos
Sai Life Sciences provides integrated development and manufacturing solutions for oligonucleotide building blocks, supporting innovators advancing RNA- and DNA-based therapeutics. Our dedicated R&D team combines deep synthetic expertise with robust process development to deliver high-quality, scalable phosphoramidites and specialty components.
Phosphoramidite Development & Manufacturing
Our experienced team develops and manufactures key building blocks for oligonucleotide synthesis at scale, including:
- Standard DNA and RNA phosphoramidites
- Modified RNA and DNA bases
- LNA (Locked Nucleic Acid) phosphoramidites
- PMO (Phosphorodiamidate Morpholino Oligomer) monomers
- Custom and novel amidite classes tailored to client needs
We routinely support complex development programs, translating laboratory routes into scalable, robust processes designed for global supply requirements.
Conjugation-Ready Components
Beyond amidites, Sai Life Sciences has extensive expertise in the development and manufacture of GalNAc clusters used in conjugated oligonucleotide therapeutics. Our capabilities support the growing demand for targeted delivery systems, particularly in liver-directed RNA therapies.
Our Capabilities
Our infrastructure is purpose-built to enable seamless scale-up from development to commercial supply:
- Non-GMP facilities – reactors up to 100 L for development and early-scale production
- GMP pilot facilities – reactors up to 350 L for clinical-stage supply
- Dedicated GMP production block – vessels up to 1500 L, specifically designed for phosphoramidite manufacturing
This combination of technical expertise and purpose-built infrastructure allows us to reliably deliver amidites and related building blocks at the scale and quality required for large, global oligonucleotide supply chains.
- Deep expertise in modified nucleotide chemistry
- Proven large-scale amidite manufacturing capability
- Dedicated infrastructure for GMP production
- Experience supporting complex, global supply programs
With strong R&D depth and scalable manufacturing platforms, Sai Life Sciences is positioned as a trusted partner for the development and supply of high-value oligonucleotide building blocks.