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Discovery Biology Laboratory
Greater Boston, USA

The Sai Life Sciences Discovery Biology Laboratory is located in Greater Boston, one of the world’s leading life sciences and biotechnology clusters. The location enables close, real-time collaboration with start-ups, emerging biotechs, and global innovators working at the forefront of drug discovery.

The laboratory provides exploratory biology services for complex and fast-moving research programs, including novel target interrogation, rapid assay development, early validation studies, and iterative hypothesis testing across multiple modalities and disease areas. It operates as part of Sai Life Sciences’ fully integrated global discovery biology platform, combining close collaboration in the US with deep scientific capability, scale, and execution strength in India. 

Site Highlights

  • Purpose-built for exploratory biology and early discovery
  • Advanced cellular, biochemical and biophysical platforms
  • Expert scientists driving assay development and target validation
  • Integrated with India-based teams for speed and scale
  • Flexible environment for complex, evolving programs
  • Designed for close scientific collaboration
  • Secure infrastructure to protect client IP

Our Services

We offer fit-for-purpose exploratory biology tailored to program needs, spanning early target interrogation through mechanism validation and lead support. Our teams in the US and India work in an integrated manner to ensure continuity from assay development through data generation and interpretation. 

Novel assay development (biochemical, cellular, biophysical and phenotypic)

  • Co-culture assays
  • Whole blood stimulation assays
  • Receptor quantification and binding (flow based)
  • Primary cell models
Novel Assay Development

Target and biomarker identification and validation

  • siRNA, shRNA, ASO, CRISPR
Target & Biomarker Validation

Mechanism of action (MoA) studies and pathway interrogation

  • mTOR, NFkB, GPCR target validation
  • Orthogonal assay validation
Mechanism of Action Studies

Cell-based assays and high-content screening

  • Receptor quantification and internalization
  • Neurite outgrowth of iPSC derived neuronal cell types
  • Reactive Oxygen Species (ROS) protection assays
  • Translocation quantitative assay
  • Transfection efficiency quantification
  • Phenotypic and functional assays
High-Content Cell Assays

Cellular target engagement and in vitro biomarker assessment

  • NanoBRET cell-based assays
  • FRET/TR-FRET assays
  • AlphaLISA assays
  • Fluorescence Polarization (FP)
  • Palmitic acid competition assays
Target Engagement & Biomarkers

Reagent qualification and assay robustness optimization

  • Cell line screen, cell density, kinetics, drug dose optimization
  • Agonist and antagonist mode validation
  • Antibody screen, titration, and saturation
  • LOD and LOQ determination
Assay Optimization

Biophysics (SPR & MST)

  • Affinity screening
  • Small molecules, PROTACS, Peptides, Large molecules
  • Fragment screening hit identification, confirmation, validation
  • Fragment library screening services
Biophysics (SPR & MST)

Comprehensive fragment screening and hit confirmation

Comprehensive fragment screening and hit confirmation 

Fragment Screening

The Boston Advantage

Proximity & Next-door lab concept within USA for in vitro biology services for rapid turnaround times
• Routine biochemical & biophysical assays: 3 days
• Routine cellular assays: 5 days
• Cell line generation: 4 weeks
• Thorough validation of every assay
• Reproducibility ensured 

Boston Team

Maneesh Pingle

Executive Vice President &
Head of Discovery Services

Sonela Cavicke

Head of Discovery
Business Development

Carlos Pedraza

Associate Vice President,
Discovery Services

Ajita Singh

Associate Director
Biology

Gavin Histen

Principal Scientist
Biology

Testimonials

Auron has used Sai’s biology services for the past year and we have been extremely happy with their work. Not only do they perform carefully executed experiments and deliver the data in a timely manner, their technical expertise contributed to the experimental design and interpretation of the results which enabled us to rapidly generate critical data for our drug discovery programs.
Dr Katherine YenFounder & CEO, Auron Therapeutics
The Sai team was quick to develop a workplan and kick-off the experiments to address our assay development needs, and their presence in Cambridge really expedited the project. We’ve been very happy with their rigor and speed and we will definitely continue to work with them.
AI SchroederCo-Founder & Director of R&D, Eikonizo Therapeutics

Related Resources

  • News

Sai Life Sciences hosts Biotech Pitch Day 2026 at Boston Site

Sai Life Sciences successfully hosted its Biotech Pitch Day 2026 at its Boston-area site on March 19, bringing together a dynamic group […]

20 Apr 2026

Mabtech and Sai Life Sciences Announce Strategic Collaboration to Advance Immunology Research with EYRA Platform at Sai Boston Site

Mabtech, a global life science tools company specializing in advanced immunoassays, and Sai Life Sciences, a leading integrated Contract Research, […]

28 Jan 2026

Sai Life Sciences expands suite of cellular analysis platforms in Cambridge, MA

Sai Life Sciences today announced the addition of state-of-the-art cellular analysis platforms at its Discovery Biology facility in Cambridge, Massachusetts, […]

10 Sep 2020

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